ONE HEALTH SURVEILLANCE OF ANTIMICROBIAL USE AND RESISTANCE: CHALLENGES AND SUCCESSES OF IMPLEMENTING SURVEILLANCE PROGRAMS IN SRI LANKA

One Health Surveillance of Antimicrobial Use and Resistance: Challenges and Successes of Implementing Surveillance Programs in Sri Lanka

Background: Sri Lanka is a low-income country, as defined by the World Bank.The country suffered further economic downturn during the COVID-19 pandemic.This situation adversely affected the prioritization of policies and programs around healthcare and public health.In particular, inflation, fuel prices, and shortage of food supplies increased strug

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Targeted therapy in NPM1-mutated AML: Knowns and unknowns

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of myeloid hematopoietic stem/progenitor cells.NPM1 represents the most frequently mutated gene in AML and approximately 30% of AML cases carry NPM1 mutations.Mutated NPM1 result in the cytoplasmic localization of bushranger awning NPM1 (NPM1c).NPM1c in

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